Potencial terapéutico de la manzanilla y la valeriana en la salud animal: una revisión integrativa, retos actuales y perspectivas futuras

Authors

DOI:

https://doi.org/10.57188/manglar.2026.023

Keywords:

Matricaria chamomilla, Valeriana officinalis, salud animal, fitoterapia, bienestar animal

Abstract

La búsqueda de alternativas naturales para mejorar la salud y el bienestar animal ha impulsado el interés en plantas medicinales como la manzanilla (Matricaria chamomilla L.) y la valeriana (Valeriana officinalis L.). Ambas poseen compuestos bioactivos con efectos ansiolíticos, sedantes, antioxidantes e inmunomoduladores, cuya acción sinérgica puede contribuir a reducir el estrés y optimizar el rendimiento productivo en animales de interés zootécnico. Esta revisión analiza la composición fitoquímica de ambas plantas, sus mecanismos de acción sobre el sistema nervioso central, sus aplicaciones documentadas en producción animal, y compara su eficacia y perfil de seguridad con fármacos convencionales. La búsqueda se realizó en Scopus, Web of Science y SciELO, considerando publicaciones de los últimos diez años. Los resultados indican que la apigenina de la manzanilla y el ácido valerénico de la valeriana actúan principalmente sobre los receptores GABA-A, ejerciendo efectos ansiolíticos y sedantes con baja toxicidad reportada en diversas especies. Ambas plantas presentan además propiedades antioxidantes e inmunomoduladoras de relevancia para el bienestar animal. Se concluye que la manzanilla y la valeriana representan alternativas naturales seguras y sostenibles para promover el bienestar y la productividad animal, aunque se requieren más estudios que estandaricen dosis, métodos de administración y evaluaciones toxicológicas a largo plazo en condiciones productivas reales.

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References

Abd El-Hack, M. E., Ismail, I. E., Khalaf, Q. A. W., Khafaga, A. F., Khalifa, N. E., Khojah, H., Abusudah, W. F., Qadhi, A., Almohmadi, N. H., & Imam, M. S. (2024). Chamomile: Functional properties and impacts on poultry/small ruminant health and production – A Review. Annals of Animal Science, 24(2), 349–365. https://doi.org/10.2478/aoas-2023-0062

Ak, K., Minaz, M., Er, A., & Aslankoç, R. (2022). The using potential of a new natural anesthetic agent on rainbow trout (Oncorhynchus mykiss): Chamomile oil (Matricaria chamomilla). Aquaculture, 561, 738742. https://doi.org/10.1016/j.aquaculture.2022.738742

Almeida, M. C. D., Souza, R. V. D., Santos, G. S. D., Barros, J. A., & Nicolussi, A. C. (2025). Depressive symptoms, anxiety, stress, and the use of medicinal plants by nursing students. Revista Gaúcha de Enfermagem, 46, e20240244. https://doi.org/10.1590/1983-1447.2025.20240244.en

Alvarado García, P. A. A., Soto-Vasquez, M. R., Rodrigo Villanueva, E. M., Gavidia Valencia, J. G., Guzman Rodriguez, N. M., Rengifo Penadillos, R. A., Campos Florian, J. V., & Rodriguez De Guzman, Y. E. (2024). Chamomile (Matricaria chamomilla L.) essential oil and its potential against stress, anxiety, and sleep quality. Pharmacognosy Journal, 16(1), 100–107. https://doi.org/10.5530/pj.2024.16.14

Ascate-Pasos, M. E., Ganoza-Yupanqui, M. L., Suárez-Rebaza, L. A., & Bussmann, R. W. (2020). Valeriana pilosa Ruiz & Pav.: Una revisión de usos tradicionales, fitoquímica y farmacología. Ethnobotany Research and Applications, 20. https://doi.org/10.32859/era.20.19.1-15

Bączek, K. B., Kosakowska, O., Boczkowska, M., Bolc, P., Chmielecki, R., Pióro-Jabrucka, E., Raj, K., & Węglarz, Z. (2022). Intraspecific variability of wild-growing common valerian (Valeriana officinalis L.). Plants, 11(24), 3455. https://doi.org/10.3390/plants11243455

Bao, H., Pan, X., Tao, Q., Zhang, G., Ding, W., Li, G., Peng, D., Du, B., & Li, P. (2024). Safety evaluation of aqueous extract from Valeriana officinalis L. roots: Genotoxicity, acute, subchronic and teratology toxicity. Journal of Ethnopharmacology, 335, 118687. https://doi.org/10.1016/j.jep.2024.118687

Barcin-Güzeldere, H. K., Büyükuslu, N., & İduğ, T. (2022). The effect of chamomile extract on blood sugar level, lipid profile and body weight in high-fat diet fed rats. ACTA Pharmaceutica Sciencia, 60(2), 207. https://doi.org/10.23893/1307-2080.APS.6014

Benali, T., Laghmari, M., Touhtouh, J., Aanniz, T., Lemhadri, A., Daoudi, M. D., Bouyahya, A., Lee, L.-H., Ullah, R., Alotaibi, A., Akhazzane, M., Zengin, G., & Hammani, K. (2024). Chemical composition and bioactivity of essential oils from Cistus ladanifer L., Pistacia lentiscus L., and Matricaria chamomilla L. Biochemical Systematics and Ecology, 116, 104880. https://doi.org/10.1016/j.bse.2024.104880

Bora, B., Yin, T., Zhang, B., Altan, C. O., & Benjakul, S. (2025). Comparison between Indian and commercial chamomile essential oils: Chemical compositions, antioxidant activities and preventive effect on oxidation. Food Chemistry: X, 26, 102292. https://doi.org/10.1016/j.fochx.2025.102292

Borrás, S., Martínez-Solís, I., & Ríos, J. L. (2021). Medicinal plants for insomnia related to anxiety: An updated review. Planta Medica, 87(10/11), 738–753. https://doi.org/10.1055/a-1510-9826

Cáceres, R., Perinango, J., Chilón, D., Paredes, M., Vilela, L., Zambrano, L., & Tafur, L. (2024). Efecto de la manzanilla (Chamaemelum nobile) en agua de bebida sobre el rendimiento productivo y salud de la codorniz ponedora. Revista de Investigaciones Veterinarias del Perú, 35(2), e27853. https://doi.org/10.15381/rivep.v35i2.27853

Caudal, D., Guinobert, I., Lafoux, A., Bardot, V., Cotte, C., Ripoche, I., Chalard, P., & Huchet, C. (2018). Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. Journal of Traditional and Complementary Medicine, 8(2), 335–340. https://doi.org/10.1016/j.jtcme.2017.06.011

Çelik, C., & Kırmızıbekmez, H. (2025). The genus Valeriana L.: Ethnopharmacology, phytochemistry and biological activities – An updated review. Phytochemistry Reviews. https://doi.org/10.1007/s11101-024-10061-x

Cevik, C., Ercan, A. M., & Or, M. E. (2025). Multimodal assessment of Hericium erinaceus and Valeriana officinalis for canine anxiety: Integrating EEG, neurochemical analysis, and behavioral surveys. Journal of Veterinary Behavior, 80, 57–68. https://doi.org/10.1016/j.jveb.2025.04.010

Chandra Shekhar, H., Joshua, L., & Thomas, J. V. (2024). Standardized extract of Valeriana officinalis improves overall sleep quality in human subjects with sleep complaints. Advances in Therapy, 41(1), 246–261. https://doi.org/10.1007/s12325-023-02708-6

Chaves, P. F. P., Hocayen, P. D. A. S., Dallazen, J. L., De Paula Werner, M. F., Iacomini, M., Andreatini, R., & Cordeiro, L. M. C. (2020). Chamomile tea: Source of a glucuronoxylan with antinociceptive, sedative and anxiolytic-like effects. International Journal of Biological Macromolecules, 164, 1675–1682. https://doi.org/10.1016/j.ijbiomac.2020.08.039

Choi, H.-S., Hong, K.-B., Han, S. H., & Suh, H. J. (2018). Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model. Biomedicine & Pharmacotherapy, 99, 913–920. https://doi.org/10.1016/j.biopha.2018.01.159

Das, G., Shin, H.-S., Tundis, R., Gonçalves, S., Tantengco, O. A. G., Campos, M. G., Acquaviva, R., Malfa, G. A., Romano, A., Robles, J. A. H., Clores, M. Q., & Patra, J.-K. (2021). Plant species of sub-family Valerianaceae – A review on its effect on the central nervous system. Plants, 10(5), 846. https://doi.org/10.3390/plants10050846

Ebrahimi, H., Mardani, A., Basirinezhad, M. H., Hamidzadeh, A., & Eskandari, F. (2022). The effects of lavender and chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community-dwelling people. EXPLORE, 18(3), 272–278. https://doi.org/10.1016/j.explore.2020.12.012

El-Alfy, A. T., Almeida, K., Vaidya, N., & Abourashed, E. A. (2025). Inhibition of an endocannabinoid catabolizing enzyme is a potential mechanism for the anxiolytic effect of chamomile. Journal of Ethnopharmacology, 353, 120312. https://doi.org/10.1016/j.jep.2025.120312

Fernandes, J., Reboredo, F. H., Luis, I., Silva, M. M., Simões, M. M., Lidon, F. C., & Ramalho, J. C. (2022). Elemental composition of commercial herbal tea plants and respective infusions. Plants, 11(11), 1412. https://doi.org/10.3390/plants11111412

Gammoh, O., Aburubaiha, Z., Mayyas, A., Alkatib, W., Masarweh, R., Elhajji, F., & Alqudah, A. (2023). Valerian and hops combination versus escitalopram in models of depression and anxiety. Jordan Journal of Pharmaceutical Sciences, 16(1), 124–136. https://doi.org/10.35516/jjps.v16i1.1073

Hafez Ahmed, M. Z., Hassan Elfiky, M. A., Elsayed Mohamed, E. E., Ibrahim Thabet, R. H., Gad Allah, A. M., & Adel, G. (2024). Influence of chamomile leaves extract in different doses on renal functions and diabetic indices in streptozotocin-induced diabetic rat. Pharmacognosy Journal, 16(5), 1029–1035. https://doi.org/10.5530/pj.2024.16.166

Homami, S. S., Jaimand, K., Rezaee, M. B., & Afzalzadeh, R. (2016). Comparative studies of different extraction methods of essential oil from Matricaria recutita L. in Iran. Journal of the Chilean Chemical Society, 61(2), 2982–2984. https://doi.org/10.4067/S0717-97072016000200026

Hosseini, S. M., Zanganeh, S., & Qaraaty, M. (2025). The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers. Avicenna Journal of Phytomedicine, 15(1). https://doi.org/10.22038/ajp.2024.24974

Iacob, R., Palimariciuc, M., Florea, T., Pricope, C. V., Uritu, C. M., Tamba, B. I., & Hritcu, L. (2024). Evaluation of the therapeutical effect of Matricaria chamomilla extract vs. galantamine on animal model memory and behavior using 18F-FDG PET/MRI. Current Issues in Molecular Biology, 46(5), 4506–4518. https://doi.org/10.3390/cimb46050273

Ioniță, R. (2019). Anxiolytic and antidepressant effects of Matricaria chamomilla hydroalcoholic extract in a rat model of scopolamine. FARMACIA, 67(1), 68–72. https://doi.org/10.31925/farmacia.2019.1.9

Khalid, Z., Noreen, S., Aja, P. M., Rehman, A., & Sadiqa, A. (2025). Comparative effect of chamomile flower (Matricaria chamomilla L.) and passion flower (Passiflora incarnata L.) powder tea in patients suffering from primary insomnia. CyTA - Journal of Food, 23(1), 2504527. https://doi.org/10.1080/19476337.2025.2504527

Khan, G. U., Khan, S. S., Naeem, S., Awan, A. N., Siddiqui, F., Siddiqui, H., Shuja, A. A., & Tahir, A. (2025). Matricaria chamomilla L. leaf and flower extracts improved scopolamine-induced amnesia via regulation of cholinergic dysfunction and brain antioxidant status. Journal of Ethnopharmacology, 352, 120141. https://doi.org/10.1016/j.jep.2025.120141

Liu, J.-J., Hao, J.-J., Tan, M., Liao, C.-C., Liu, D., Li, H.-M., & Li, R.-T. (2024). Iridoids and other constituents from the leaves and stems of Valeriana officinalis var. latifolia. Phytochemistry, 218, 113934. https://doi.org/10.1016/j.phytochem.2023.113934

Mohamed, R. S., Alagawany, M., Attia, A. I., Ismail, F. S. A., Salah, A. S., Di Cerbo, A., Azzam, M. M., Arafa, M. M., & El-Mekkawy, M. M. (2024). The role of chamomile oil against ochratoxin A in quail breeders: Productive and reproductive performances, egg quality, and blood metabolites. Poultry Science, 103(3), 103440. https://doi.org/10.1016/j.psj.2024.103440

Mokhtari, A., Omidi, M., Ebrahimi, M., Alizadeh, H., Sobhani, A., Azadi, P., Noormohammadi, N., & Shafaie, M. (2024). Optimizing the extract yield of bioactive compounds in Valeriana officinalis root: A D-optimal design. Preparative Biochemistry & Biotechnology, 54(6), 838–848. https://doi.org/10.1080/10826068.2023.2297709

Montañez Calero, T., Díaz Coahila, D., Angulo Herrera, P., Cerro Temoche, L., Cruz-Castellón, C., Vasquez-Quispesivana, W., & Lázaro De La Torre, C. A. (2022). Efecto sedante de un extracto alcohólico de Valeriana sp. en alevinos de tilapia (Oreochromis niloticus) para la reducción de estrés durante transporte simulado. Revista de Investigaciones Veterinarias del Perú, 33(3), e21063. https://doi.org/10.15381/rivep.v33i3.21063

Moraleco, D. D., Lima, H. J. D., Morais, M. V. M., Bittencourt, T. M., Valentim, J. K., & Silva, L. G. D. (2023). Impact of herbal medicines use on the welfare of laying Japanese quails. Revista Acadêmica Ciência Animal, 21. https://doi.org/10.7213/acad.2023.21001

Nasser Hussein, M., & Noory Fajer, A. (2024). In vivo evaluation of antioxidant activity of chamomile extract against procyclidine-induced oxidative stress. Asian Pacific Journal of Cancer Prevention, 25(8), 2919–2928. https://doi.org/10.31557/APJCP.2024.25.8.2919

Olascuaga-Castillo, K. A., Castillo-Medina, O., Villacorta-Zavaleta, M., Diaz-Ortega, J., Blanco-Olano, C., Altamirano-Sarmiento, D., & Valdiviezo-Campos, J. (2024). Extraction of essential oils by hydrodistillation of four aromatic species: Conditioning, extraction conditions, yield and chemical composition. Scientia Agropecuaria, 15(3), 385–408. https://doi.org/10.17268/sci.agropecu.2024.029

Pinder, N. E., Ligocki, I. Y., Horton, B. M., & Hoover, J. E. (2024). Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice. Behavioural Brain Research, 457, 114717. https://doi.org/10.1016/j.bbr.2023.114717

Raal, A., Kokitko, V., Odyntsova, V., Orav, A., & Koshovyi, O. (2024). Comparative analysis of the essential oil of the underground organs of Valeriana spp. from different countries. Phyton, 93(7), 1365–1382. https://doi.org/10.32604/phyton.2024.053754

Raj, K., Węglarz, Z., Przybył, J., Kosakowska, O., Pawełczak, A., Gontar, L., Puchta-Jasińska, M., & Bączek, K. (2023). Chemical diversity of wild-growing and cultivated common valerian (Valeriana officinalis L. s.l.) originating from Poland. Molecules, 29(1), 112. https://doi.org/10.3390/molecules29010112

Ranjbar, M., Mazaheri, M., Ansaripour, M., Babaeian, M., Jalali, A., & Zarshenas, M. M. (2022). Herbal medications to manage insomnia: An overview of clinical trials using herbal treatment for insomnia. Traditional and Integrative Medicine. https://doi.org/10.18502/tim.v7i2.9928

Rogosic, J., Saric, T., & Zupan, I. (2015). Effect of Achillea millefolium L. and Matricaria chamomilla L. on consumption of Juniperus oxycedrus L. and J. phoenicea L. by goats. Annals of Animal Science, 15(1), 119–127. https://doi.org/10.2478/aoas-2014-0060

Ross, D. J., & Roberts, J. L. (2018). Equine calming products: A short survey into their use, effect, and knowledge using a small sample of horse owners in the north of Scotland, UK. Journal of Equine Veterinary Science, 68, 63–67. https://doi.org/10.1016/j.jevs.2018.05.208

Sayyar, Z., Yazdinezhad, A., Hassan, M., & Jafari Anarkooli, I. (2018). Protective effect of Matricaria chamomilla ethanolic extract on hippocampal neuron damage in rats exposed to formaldehyde. Oxidative Medicine and Cellular Longevity, 2018, 6414317. https://doi.org/10.1155/2018/6414317

Senn, R., Schertler, L., Bussmann, H., Drewe, J., Boonen, G., & Butterweck, V. (2025). Valerenic acid and pinoresinol as positive allosteric modulators: Unlocking the sleep-promoting potential of valerian extract Ze 911. Molecules, 30(11), 2344. https://doi.org/10.3390/molecules30112344

Sepp, J., Koshovyi, O., Jakstas, V., Žvikas, V., Botsula, I., Kireyev, I., Tsemenko, K., Kukhtenko, O., Kogermann, K., Heinämäki, J., & Raal, A. (2024). Phytochemical, technological, and pharmacological study on the galenic dry extracts prepared from German chamomile (Matricaria chamomilla L.) flowers. Plants, 13(3), 350. https://doi.org/10.3390/plants13030350

Soliman, G. A. (2020). The potential cardioprotective effect of Matricaria chamomilla extract against diabetes-induced oxidative stress in rats. FARMACIA, 68(2), 269–279. https://doi.org/10.31925/farmacia.2020.2.12

Suleiman, S. D., & Hassan, J. S. (2022). Anticonvulsant and antioxidant activities of crude flavonoid extract of Matricaria chamomilla L. against convulsions induced by pentylenetetrazole in chicks. Iraqi Journal of Veterinary Sciences, 36(4), 1089–1095. https://doi.org/10.33899/ijvs.2022.133120.2176

Torres-Hernández, B. A., Del Valle-Mojica, L. M., & Ortíz, J. G. (2015). Valerenic acid and Valeriana officinalis extracts delay onset of pentylenetetrazole (PTZ)-induced seizures in adult Danio rerio (Zebrafish). BMC Complementary and Alternative Medicine, 15(1), 228. https://doi.org/10.1186/s12906-015-0731-3

Toso, F., Ardoino, S., Harfierld, L., & Benitez, V. (2022). Efecto sobre la motilidad gástrica en ratones de Equisetum giganteum L., Cortaderia selloana, Anthemis cotula L. y Atriplex undulata. Ciencia Veterinaria, 24(2), 1–8. https://doi.org/10.19137/cienvet202224203

Varshney, M., Saha, S., Prinsa, P., & Jakhmola, V. (2024). Sleep disorder and its treatment: From nature to laboratory. Majalah Obat Tradisional, 29(1), 14. https://doi.org/10.22146/mot.86645

Vasileva, L. V., Ivanovska, M. V., Murdjeva, M. A., Saracheva, K. E., & Georgiev, M. I. (2019). Immunoregulatory natural compounds in stress-induced depression: An alternative or an adjunct to conventional antidepressant therapy? Food and Chemical Toxicology, 127, 81–88. https://doi.org/10.1016/j.fct.2019.03.004

Vázquez-Carrillo, M. F., Montelongo-Pérez, H. D., González-Ronquillo, M., Castillo-Gallegos, E., & Castelan-Ortega, O. A. (2020). Effects of three herbs on methane emissions from beef cattle. Animals, 10(9), 1671. https://doi.org/10.3390/ani10091671

Wang, S.-N., Yao, Z.-W., Zhao, C.-B., Ding, Y.-S., Jing-Luo, Bian, L.-H., Li, Q.-Y., Wang, X.-M., Shi, J.-L., Guo, J.-Y., & Wang, C.-G. (2021). Discovery and proteomics analysis of effective compounds in Valeriana jatamansi Jones for the treatment of anxiety. Journal of Ethnopharmacology, 265, 113452. https://doi.org/10.1016/j.jep.2020.113452

Wlazło, L., Ossowski, M., Kasela, M., Bis-Wencel, H., Zebracka, A., Chmielowiec-Korzeniowska, A., & Nowakowicz-Debek, B. (2022). Relaxer feed additive as a natural tranquilizer for farmed mink (Neovison vison) in stress situations. Medycyna Weterynaryjna, 78(06), 6668–2022. https://doi.org/10.21521/mw.6668

Zeni, F., De Liz, M. P., Duarte, D., & Zeni, A. L. B. (2021). Plantas medicinais e fitoterapéuticos na promoção à saúde no transtorno de ansiedade: Uma revisão da literatura de apoio aos profissionais. Infarma - Ciências Farmacêuticas, 33(1), 6–17. https://doi.org/10.14450/2318-9312.v33.e1.a2021.pp6-17

Zhang, D., Zhang, Z., Wu, G., Sun, Y., Jiang, Y., Zhang, H., Wang, W., Song, X., & Li, Y. (2022). Iridoids and lignans from Valeriana officinalis L. and their cytotoxic activities. Phytochemistry Letters, 49, 125–130. https://doi.org/10.1016/j.phytol.2022.03.018

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2026-06-30

How to Cite

Chavez-Paredes, N. A., Honorio-Javes, C. E., & Pajuelo-Risco, F. (2026). Potencial terapéutico de la manzanilla y la valeriana en la salud animal: una revisión integrativa, retos actuales y perspectivas futuras. Manglar, 23(2), 243-255. https://doi.org/10.57188/manglar.2026.023

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