Fisiopatología de la enfermedad pulmonar obstructiva crónica (EPOC)
Pathophysiology of chronic obstructive pulmonary disease (COPD)
DOI:
https://doi.org/10.57188/ricsa.2026.005Palabras clave:
Enfermedad Pulmonar Obstructiva Cro´nica; Obstruccio´n de las Ví´as Ae´reas; Enfisema Pulmonar; Intercambio Gaseoso; Remodelacio´n de las Ví´as Ae´reas. (Fuente: DeCS-BIREME)Resumen
La enfermedad pulmonar obstructiva cro´nica (EPOC) es una patologí´a respiratoria progresiva caracterizada por limitacio´n persistente y no completamente reversible del flujo ae´reo, secundaria a una respuesta inflamatoria cro´nica frente a partí´culas nocivas, principalmente el humo del tabaco. Su fisiopatologí´a incluye inflamacio´n cro´nica, remodelado bronquial, aumento de la resistencia de la ví´a ae´rea, destruccio´n del pare´nquima pulmonar con pe´rdida de elasticidad (enfisema) y atrapamiento ae´reo. Estas alteraciones condicionan deterioro del intercambio gaseoso. Asimismo, la EPOC se asocia a manifestaciones siste´micas como disfuncio´n diafragma´tica e hipertensio´n pulmonar secundaria. La comprensio´n integral de estos mecanismos permite optimizar el manejo clí´nico y las estrategias preventivas, especialmente en contextos con acceso limitado a servicios de salud, como el norte del Peru´.
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Derechos de autor 2026 Roy F. Sanchez Suyo, Xiomara Y. Saldaña Sagastegui, Genesis A. Rodriguez Ancachi, Rubi Y. Rosas
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
RICSA is an open access journal distributed under the terms and conditions of Creative Commons Attribution 4.0 International license
