Apgar Score at Birth as a Predictor of Neonatal Death in a Regional Hospital in Northern Peru, 2018–2023

Apgar al nacer como predictor de muerte neonatal en un hospital regional del norte del Perú, 2018-2023

Authors

  • Mauro Pablo Meza Olivera Universidad Nacional de Tumbes, Escuela Profesional de medicina humana, Tumbes, Perú. , Servicio de Neonatología, Hospital Regional JAMO II-2, Tumbes, Perú. , Médico Pediatra, Doctor en Ciencias de la Salud.
  • Heidy Lisbeth Villavicencio Boyer Universidad Nacional de Tumbes, Escuela Profesional de medicina humana, Tumbes, Perú.
  • Percy Mc-Quen Vílchez Barreto Universidad Peruana Cayetano Heredia, Centro de Salud Global Tumbes, Perú.

DOI:

https://doi.org/10.57188/

Keywords:

Apgar score, positive predictive value, neonatal mortality, perinatal asphyxia.

Abstract

Objective: To determine the predictive value of one and five-minute Apgar scores as factors associated with neonatal death (ND) at the JAMO Regional Hospital, Tumbes. Materials and methods: Quantitative, analytical, and cross-sectional study. The sample included 114 records of deceased neonates (2018-2023). Generalized Linear Models (GLM) were used to calculate prevalence ratios (PR) with 95% CI. Results: An Apgar score ≤3 at five minutes predicted a higher risk of early neonatal death (END) with a Positive Predictive Value (PPV) of 70.0%. Perinatal asphyxia (p<0.001) and eutocic delivery (p=0.036) were significantly associated with severe neonatal depression. Multivariate analysis confirmed that severe depression increases the probability of asphyxia as the underlying cause of death by 2.96 times. Conclusions: The five-minute Apgar score is a robust predictor of early ND, validated as a marker of resuscitation failure. Asphyxia remains a key determinant of fatal outcomes.

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References

1. OMS [Internet]. 2024 [cited 2025 Aug 14]. Salud materna. Available from: https://www.paho.org/es/temas/salud-materna

2. Organización Panamericana de la Salud. Desigualdades en la mortalidad infantil en la Región de las Américas: elementos básicos para el análisis. OPS Boletín Epidemiológico;22(2),2001. 2001.

3. Paulson KR, Kamath AM, Alam T, Bienhoff K, Abady GG, Abbas J, et al. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. The Lancet. 2021;398(10303):870–905. doi:10.1016/S0140-6736(21)01207-1

4. Chilipio-Chiclla MA, Atencio-Castillo KE, Santillán-Árias JP. Perinatal low five-minutes apgar predictors at in a peruvian hospital. Revista de la Facultad de Medicina Humana . 2021;21(1):40–9. doi:10.25176/RFMH.V21I1.3345

5. Calle-Munzón. Factores de riesgo de mortalidad neonatal: revisión sistemática. Pro Sciences: Revista de Producción, Ciencias e Investigación. 2021;5(40):312–29. doi:10.29018/issn.2588-1000vol5iss40.2021pp312-329

6. Ticona R. M, Huanco A. D. Mortalidad Perinatal Hospitalaria En El Perú: Factores De Riesgo. Rev Chil Obstet Ginecol. 2005;70(5). doi:10.4067/s0717-75262005000500006

7. Viera OA, Rendon MT, Apaza DH. Perinatal outcome of newborns with low Apgar score at the Hospital Hipólito Unanue Tacna-Peru, 2002-2016. Revista Peruana de Ginecologia y Obstetricia. 2019;65(1):21–6. doi:10.31403/RPGO.V65I2147

8. Huicho LA. Examining national and district-level trends in neonatal health in Peru. BMC Public Health. 2016;16(3):281–2. doi:10.1186/s12889-016-3405-2

9. Laqui Farfan L. Factores neonatales y maternos asociados a mortalidad neonatal - Hospital Regional Tumbes 2020-2022. 2020;2020–2.

10. Ministerio de Salud-Peru. Programa presupuestal: Programa presupuestal 002 salud materno neonatal. Resolución Directoral N° 024–2016-EF/5001. 2021;1(2):281.

11. Monasterio Huertas RF. Factores asociados a la mortalidad neonatal del Hospital Regional jose alfredo mendoza Olavarria Jamo II-2 de Tumbes en el año 2017. Universidad Nacional de Piura; 2018.

12. INEI. Indicadores de Resultados de los Programas Presupuestales, 2014 - 2019. Encuesta Demográfica y de Salud Familiar. 2020.

13. Razaz N, Norman M, Alfvén T, Cnattingius S. Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease: a nationwide population-based study of term infants. The Lancet Regional Health - Europe. 2023;24:100532. doi:10.1016/j.lanepe.2022.100532

14. Cnattingius S, Johansson S, Razaz N. Apgar Score and Risk of Neonatal Death among Preterm Infants. New England Journal of Medicine. 2020;383(1):49–57. doi:10.1056/nejmoa1915075

15. Forsblad K, Källén K, Marsál K, Hellström-Westas L. Apgar score predicts short-term outcome in infants born at 25 gestational weeks. Acta Paediatr. 2007 Feb;96(2):166–71. doi:10.1111/j.1651-2227.2007.00099.x

16. Ahmed KY, Thapa S, Hassen TA, Tegegne TK, Dadi AF, Odo DB, et al. Population modifiable risk factors associated with neonatal mortality in 35 sub-Saharan Africa countries: analysis of data from demographic and health surveys. EClinicalMedicine. 2024;73:1–12. doi:10.1016/j.eclinm.2024.102682

17. Dalili H, Sheikh M, Hardani AK, Nili F, Shariat M, Nayeri F. Comparison of the combined versus conventional apgar scores in predicting adverse neonatal outcomes. PLoS One. 2016;11(2):1–11. doi:10.1371/journal.pone.0149464

18. Score TA. The Apgar Score. Obstetrics and Gynecology. 2015;126(4):E52–5. doi:10.1097/AOG.0000000000001108

19. OMS. Protocolo de atención al recién nacido con asfixia perinatal y encefalopatía hipóxico-isquémico. Vol. 11. 2019;11(1):1–14.

20. Pública M de S. Atención Neonatal. 2016. 346–352 p.

21. Mota-Rojas D, Villanueva-García D, Solimano A, Muns R, Ibarra-Ríos D, Mota-Reyes A. Pathophysiology of Perinatal Asphyxia in Humans and Animal Models. Biomedicines. 2022;10(2). doi:10.3390/biomedicines10020347

22. Rivera Miranda MA, Lara Latambe NT, Baró Bouly T. Asphyxia at birth: maternal risk factors and their impact on neonatal mortality Asfixia. Revista de Información Científica. 2018;97(5):11.

23. Cansino-Vega RA. Asfixia Inicial perinatal- neonatal. Revista Médica MD. 2009;1(4):1–8.

24. Veloso FCS, Barros CRA, Kassar SB, Gurgel RQ. Neonatal death prediction scores: A systematic review and meta-analysis. BMJ Paediatr Open. 2024;8(1):1–10. doi:10.1136/bmjpo-2024-003067

25. Pérez-Muñuzuri A, Boix H, Sánchez-Redondo MD, Cernada M, Espinosa-Fernández MG, González-Pacheco N, et al. Care levels in neonatal units in Spain: An updated vision for a new reality. An Pediatr (Engl Ed). 2023;98(4):301–7. doi:10.1016/j.anpedi.2023.02.009

26. Shukla V V, Carlo WA. Risk Prediction for Stillbirth and Neonatal Mortality in Low-resource Settings. Newborn (Clarksville, Md). 2022;1(2):215–8. doi:10.5005/jp-journals-11002-0034

27. Viera OA, Rendon MT, Apaza DH. Perinatal outcome of newborns with low Apgar score, at the Hospital Hipólito Unanue Tacna-Peru, 2002-2016. Revista Peruana de Ginecologia y Obstetricia. Peruvian Society of Obstetrics and Gynecology; 2019. p. 21–6. doi:10.31403/RPGO.V65I2147

28. Tejeda-Mariaca JE, Pizango-Mallqui O, Alburquerque-Duglio M, Mayta-Tristán P. Risk factors of small for the gestational age neonates in a hospital of lima, peru. Rev Peru Med Exp Salud Publica. 2015.

29. Dubie AG, Kokeb M, Mersha AT, Agegnehu CD. Prevalence and associated factors of perinatal asphyxia in newborns admitted to neonatal intensive care unit at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, Ethiopia. BMC Pediatr. 2021;21(1):1–8. doi:10.1186/s12887-021-03019-x

30. Kumari M, Soomro TA, Qureshi R, Kamran B, Qureshi M, Bai P. Study of Risk Factors in Children with Birth Asphyxia. Biological and Clinical Sciences Research Journal. 2025;6(5):131–4. doi:10.54112/bcsrj.v6i5.1771

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Published

2026-06-30

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How to Cite

Apgar Score at Birth as a Predictor of Neonatal Death in a Regional Hospital in Northern Peru, 2018–2023: Apgar al nacer como predictor de muerte neonatal en un hospital regional del norte del Perú, 2018-2023. (2026). RICSA, 3(2), 78-84. https://doi.org/10.57188/

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