Aqueous extract of Retama sphaerocarpa induces cytotoxic and genotoxic damage in meristematic cells of Allium sativum
DOI:
https://doi.org/10.57188/manglar.2024.040Abstract
The ingestion of aqueous extracts from medicinal plants is frequently used in Mexico to treat various diseases. Retama sphaerocarpa (R. sphaerocarpa) is a medicinal plant. However, there needs to be more information about its toxic potential. For this reason, the present study evaluated the cytotoxic, genotoxic, and cytostatic effects of the aqueous extract of R. sphaerocarpa using meristematic cells of Allium sativum (A. Sativum). Root primordia from A. sativum bulblets were exposed for 72 h to 5 g/L or 10 g/L of R. sphaerocarpa aqueous extract. Root length, presence of chromosomal aberrations and mitotic division rate were determined. The results indicate that the aqueous extract of R. sphaerocarpa (5 g/L or 10 g/L) induces cytotoxic, genotoxic, and cytostatic damage predicting its possible toxicity and evidence of possible health risks associated with its consumption.
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Copyright (c) 2024 Katia Alejo-Martínez, Héctor Javier Espíritu-Sánchez, Patricia Álvarez-Fitz, Ma. Elena Moreno-Godínez, Marco Antonio Ramírez-Vargas
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